![]() ![]() They don’t know what their bodies can do and it causes their minds to panic!” Some studies have reported people with never-medicated ADHD to have higher than normal dopamine transporter activity and some have reported lower than normal.“An Unwell Mind Some people, they do not know what it is like to struggle. "ADHD" is just a collection of symptoms, you just have to have a certain number of the symptoms and for them to be causing you problems to be diagnosed. It also depends on the person's unique brain, ADHD is complex and poorly understood and there are many types. Not all ADHD stimulants even inhibit dopamine transporters, (for example methylphenidate works in a different way). And long-term/lasting dopamine transporter reduction is not necessarily a good thing (look at meth addicts for example, many of whom are self-medicating for things like ADHD). I found it much more effective if I didn't take it regularly.Īlso inhibiting dopamine transporters is only one mechanism of Adderall. The longer I took it the less improved my focus/motivation/energy were from the same dose. I have ADD and the very first time I took Adderall I had much improved focus, motivation and energy (yet felt calmer about tasks that would normally be stressful and overwhelming to me - or that I'd normally just forget, lol - like meeting deadlines for huge projects) within 30 min or less of taking it (this was with IR, not XR). But that has not been my personal experience. Relying on the short term experience might mislead into chasing euphoria in longterm use. Short term using and long term using and both are somewhat different in their experience for the user. But I think there are really two ways to use the medication which will have different outcomes. when I read what I had written it doesn't make complete sense. I never experienced diminuished effects of my medication (only in times in which I had severe stress or in the very earliest phase of beginning the treatment). Could it then be the case that a lot of users which only take the medicine occasionally rely too much on the amphetamine euphoria component because they see this component as an indicator for the ability to function properly? But so they don't see that the ability to concentrate is more unrelated from euphoria, which leads them to chasing euphoria? This results in threads like amphetamine tolerance prevention. This kind of effect building also seems to suggest, that you have to take the medicine regularly for properly working. So euphoria and the ability to concentrate are two different (but probably related) matters. ![]() So the ability to concentrate builds day after day up and euphoria (like you indicated) decreases more and more. These transporters do reuptake the dopamine and if there are a lot of transporters, there wouldn't be enough dopamine in the synaptic cleft for enabling normal brain functions. ![]() I think that I read that this has to do with a reduction in dopamine transporter density. It is more likely that the effects, like better conentration, calmness etc., build up over the time of a week or longer. I was reading that for adults the effect of stimulants often won't be instantly. Everything else is walking with crutches. We would need to decrypt the functioning of the human body and psyche, and sophisticated technology for surveilling and delivering substances in our body. So you have a extrem complex system, which you try to control, but even doesn't know what you are exactly doing and doesn't know whats your goal. And then there is another main problem: there is no objective metric with which you can measure if the dose is right or not. Then they will also interact with each other more or less. You need to take all these variables together. If you change the dose, then the effect need to stabilize. Especially long term adaptions is something I cannot manage. Then you got interactions with other medicaments and long term adaptions. Then there are other variables like sleep or sports. So a dose for school, might be not appropriate when at home. ![]() And the doses need to be adapted to different contextes. It seems that you can accomplish different goals with different doses of the same stimulant. I think it is pretty complicated to find the right dose. ![]()
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